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On Monday night, while the “Roast of Rob Lowe” aired on Comedy Central, pharma bro and human skidmark Martin Shkreli got into a roastfest of his own on Twitter, courtesy of comedian Patton Oswalt

Shkreli, who inflated the price of HIV treatment drug Daraprim by 5,556% and was indicted on federal charges of securities fraud back in 2015, fired the first shot when he went after Oswalt for commenting on the #TrumpCantSwim trend.

RELATED: Patton Oswalt cuts the funny and opens up about his 102 days of grief

This was followed by a back-and-forth tweet throwdown that can only be described as a heavyweight boxer facing off against a middle school bully.

Hey, Shkreli, maybe you should leave the comedy to the comedians, big guy.

RELATED: Pharma exec who jacked up price of life-saving drugs is now calling this group of lawmakers “imbeciles”

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